ABSTRACT
ABSTRACT Acute retinal pigment epitheliitis (ARPE) is an idiopathic, self-limiting inflammatory retinal disorder that particularly affects healthy young individuals. The characteristic fundoscopic appearance of the acute retinal pigment epitheliitis includes a fine pigment stippling surrounded by a yellow-white hypopigmented halos in the macula. Although the exact pathogenesis of the disease remains unknown, some reports have suggested a relationship between a viral infection and acute retinal pigment epitheliitis. Acute retinal pigment epitheliitis is a rare disorder, and only single case reports or case series are found in the literature. The clinical and demographic characteristics of patients with this disease are not fully understood because of its rarity. In this study, we searched the literature to collect clinical and demographic features of the reported cases. We detail the characteristics of acute retinal pigment epitheliitis were pointed and discuss the pathogenesis of the disease.(AU)
RESUMO A epitelite pigmentar retiniana aguda (EPRA) é uma doença inflamatória idiopática e autolimitada da retina, que afeta especialmente indivíduos jovens e saudáveis. À fundoscopia, a aparência característica dessa entidade é de um pontilhado fino do pigmento, cercado de halos hiperpigmentados branco-amarelados na mácula. A patogênese exata da doença ainda é desconhecida, mas alguns relatos apontam uma relação entre epitelite pigmentar retiniana aguda e infecções virais. A epitelite pigmentar retiniana aguda é uma condição rara e na literatura há apenas relatos de casos individuais ou séries de casos. As características clínicas e demográficas da doença não são totalmente compreendidas, devido à sua raridade. Para este relato, foi feita uma busca na literatura para coletar os dados clínicos e demográficos dos casos relatados. Finalmente, são apontadas as características da epitelite pigmentar retiniana aguda e discute-se a patogênese da doença.(AU)
Subject(s)
Humans , Retinitis Pigmentosa/pathology , Epithelium/pathology , Retinal Pigments , Visual Acuity , Retinal Photoreceptor Cell Outer Segment , Circadian Clocks , c-Mer Tyrosine KinaseABSTRACT
Aim: The central corneal thickness (CCT) of healthy individuals was measured with an ultrasonic pachymeter (UP) and the Scheimpflug imaging system (SIS) and the results were compared to evaluate the agreement between the two methods in this study. Materials and Methods: The 61 subjects who had no ocular pathology or systemic disease except blepharitis were included in the study. CCT measurements of all subjects were performed with the UP (Sonomed 300P Pacscan) and SIS (Nidek Optical biometer AL-Scan) devices and the results were compared. The t test and the Bland-Altman plot were used as the statistical methods. Results: The study sample consisted of 61 cases including 20 males and 41 females. The mean age was 41.8±12.4 (20-58) years for the males and 46.2±9 (24-60) years for the females with no statistically significant difference (P=0.116). The mean CCT measurement of all the 61 subjects was 544.5±31 μm in the right eyes and 547.3±33 μm in the left eyes with UP, 530.7±27.6 μm in the right eyes and 531.6±25.5 μm in the left eyes with SIS. The CCT in the SIS results was an average of 13.8 μm thinner than the UP results in the right eye, 15.7 μm in the left eye and this difference was statistically significant (p=0.001 in right and left eyes). A high degree of agreement was found between the two methods with the Bland-Altman plot. Conclusion: A high degree of agreement was found between SIS and UP regarding CCT measurements and the mean SIS results were 13.8 μm and 15.7 μm thinner than the UP results in the right eyes and left eyes respectively.